Genotyping for NOD2 Genetic Variants and Crohn Disease: a Metaanalysis
نویسندگان
چکیده
منابع مشابه
Genotyping for NOD2 genetic variants and crohn disease: a metaanalysis.
BACKGROUND Arg702Trp, Gly908Arg, and Leu1007fsinsC variants of the NOD2 gene (nucleotide-binding oligomerization domain containing 2; alias, CARD15) influence the risk of Crohn disease. METHODS We conducted a systematic review to examine whether Arg702Trp, Gly908Arg, and Leu1007fsinsC are equally important risk factors for Crohn disease. In addition, we used studies for which combined informa...
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Purpose Identifying genetic risk factors for developing sarcoidosis-associated uveitis could provide insights into its pathogenesis which is poorly understood.We determine if variants in NOD2 confer an increased risk of developing uveitis in adults with sarcoidosis. Methods In this genetic case-control study, 51 total subjects were enrolled: 39 patients diagnosed with sarcoid-related uveitis ...
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Crohn disease (CD) exhibits a 2-4-fold increased frequency in Jews as compared with other ethnic/racial groups. Three coding variants of the NOD2/CARD15 have been reported as independent disease-predisposing mutations (DPMs), but these were found in only 30%-40% of patients with CD and could not account for all the linkage between CD and the IBD1 locus. The aim of the present study was to explo...
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of terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided article is properly cited. a Department of Pathology and Laboratory Medicine – David Geffen School of Medicine – University of California, Los Angeles/CA – USA. b Department of Pathology and Laboratory Medicine – Weill Cornell Me...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2009
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2009.127126